| abstract |
The present invention provides a gel combination comprising: polycarbophil in an amount of 1 to 5% by weight; polyvinylpyrrolidone in an amount of 4 to 8% by weight; glycerin in an amount of 1 to 10% by weight; and propylene glycol in an amount of 20 to 40% by weight; wherein: the weight ratio polyvinylpyrrolidone: polycarbophil is comprised of 1: 1 to 4: 1, the weight ratio glycerin: polycarbophil is comprised of 0.5: 1 to 2: 1, and the weight ratio propylene glycol: polycarbophil It is comprised from 8: 1 to 20: 1. The invention also provides transparent compositions comprising these gel combinations as well as processes for their preparation and use as a medicament. Due to the excipients,% by weight, and specific proportions by weight that form the combination, the resulting compositions show a high bioadhesion capacity and bioavailability of the active ingredient, without toxic adverse effects. |