http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-348917-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d3f1bfec8ac94cca9554e3c17db5c6d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0066 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J51-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 2012-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a46f594b1e0239d5ea128f9270b0e2be |
| publicationDate | 2017-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-348917-B |
| titleOfInvention | PROCESS FOR THE PRODUCTION OF ESTETROL. |
| abstract | The present invention relates to a process for the preparation of a compound of the formula (I), hydrates or solvents thereof; (I) such a process comprises the steps of (a) reacting a compound of the formula (II) with an acylating agent and a silylating agent to produce a compound of the formula (III), (II) (III) in where P1 is a protective group selected from R1CO-, or R2Si (R3) (R4) -, P2 is a protective group selected from (R6R5R7) C-CO-, or (R2) Si (R3) (R4) -, in wherein R1 is a group selected from C1-6alkyl or C3-6cycloalkyl, each group is optionally substituted by one or more substituents independently selected from fluorine or C1-4alkyl; R2, R3 and R4 are each independently a group selected from C1-6alkyl or phenyl, each group is optionally substituted by one or more substituents independently selected from fluorine or C1-4alkyl; R5 is a group selected from C1-6alkyl or phenyl, each group is optionally substituted by one or more substituents independently selected from fluorine or C1-4alkyl; R6 and R7 are each independently hydrogen or a group selected from C1-6alkyl or phenyl, each group is optionally substituted by one or more substituents independently selected from fluorine or C1-4alkyl; b) reacting the compound of the formula (III) in the presence of at least one oxidizing agent selected from a permanganate salt, osmium oxide, hydrogen peroxide or iodine and silver acetate to produce a compound of the formula (IV) ; and (IV) 5 c) Deprotect the compound of the formula (IV) to produce the compound of the formula (I). |
| priorityDate | 2011-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.