| abstract |
Compounds of formula 1, or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof are described, wherein R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C they are as defined herein, and where the YB portion and the NH-C (= X) -NH portion are in the trans configuration, they are inhibitors of TrkA kinase and are useful in the treatment of diseases that can be treated. with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. Formula. |