| abstract |
Non-natural amino acids and dolastatin analogs which include at least one unnatural amino acid, and methods for producing such unnatural amino acids and polypeptides are described herein. Dolastatin analogs may include a wide range of possible functionalities, but typically they have at least one oxime group, carbonyl, dicarbonyl and / or hydroxylamine. Also described herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, modified dolastatin analogs include at least one oxime group, carbonyl, dicarbonyl and / or hydroxylamine. Methods for using such non-natural amino acid dolastatin analogs and modified non-natural amino acid dolastatin analogs including therapeutic, diagnostic and other biotechnological uses are also described. |