| abstract |
The present invention relates to compressed tablets for oral administration containing raltegravir in the form of a pharmaceutically acceptable salt; the tablets comprise: (A) an intragranular component comprising (i) an effective amount of an alkali metal salt of raltegravir, (u) optionally a first superdisintegrant, and (iii) a binder; and (B) an extragranular component which comprises (i) a second superdisintegrant, (u) a filler, and (iii) a lubricant; Methods for preparing tablets and using tablets, optionally in combination with other anti-HIV agents, for the inhibition of HIV integrase, for the treatment or prophylaxis of HIV infection, or for treatment are also described. , delayed onset, or AIDS prophylaxis. |