| abstract |
The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. Carboxamide compounds are inhibitors of calpain (calcium-dependent cysteine proteases). Therefore, the invention also relates to the use of said carboxamide compounds to treat a disorder associated with high calpain activity. Carboxamide compounds are compounds of the general formula I, wherein R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the salts thereof suitable for pharmaceutical use. In particular, the compounds have the general formula e and Ib, where R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including tautomers thereof and pharmaceutically salts. appropriate of them. Of said compounds, those where Y is a CH2-CH2, CH2-CH2-CH2, N (RY #) - CH2, N (RY #) - CH2-CH2 or CH = CH-CH unit are preferred in each of which optionally 1 or 2 atoms of H have been replaced by identical or different RY radicals, where RY # and RY # have the meanings mentioned in the claims. |