abstract |
The present invention generally relates to 18-membered macrocyclic antimicrobial agents called Thiacumycins, specifically, OPT-80 (which is composed almost entirely of R-Thiacumycin B), pharmaceutical compositions comprising OPT-80, and methods using OPT -80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections. |