| abstract |
The present invention relates to a process for obtaining propionic acids substituted by a chromonyl radical and its esters represented by the formula: (SEE FIGURE), in which X is a phenyl radical, enyl substituted by at least one halogen, a radical lower alcohol, trihalogenomethyl, aryloxy-furyl or thienyl; and R is hydrogen; characterized in that the corresponding acetic acids are esterified with methanol, the methyl ester is transformed into the corresponding ethyl malonate by treatment with ethyl carbonate and sodium hydride, the carbanion is alcoholized with methyl iodide in diametri formamide and then proceeds to acid hydrolysis and decarboxylation of malonic acid to obtain propionic acid; the propionic acid thus obtained is reacted with an alcohol of the formula ROH in which R is an alcohol radical, -hydroxyalkyl lower, dialkyl aminoalcohyl or morpholinoethyl, or a sodium or potassium salt of said propionic acid is reacted with a alcohol halide. |