| abstract |
The present disclosure describes thiazole pyridine carboxamide derivatives of formula (I), or its pharmaceutically acceptable salt, characterized in that: X is C or N; A, B, and D are rings; the - bond represents a normalized bond where the aromatic ring contains both an N and X, which are formally represented by a C=C bond when X is C and a single bond when X is N; ring A is of the formula (A-1) or (A-2): where E1 and E2 are rings; their compositions and methods of use. The compounds inhibit the activity of Pim kinases and are useful in the treatment of diseases related to Pim kinase activity including, for example, cancer and other diseases. |