| titleOfInvention |
DERIVATIVES OF 10-(DI(PHENYL)METHYL)-4-HYDROXY-8,9,9A,10-TETRAHYDRO-7H -PYRROL[1',2':4,5]PYRAZINO[1,2-B]PYRIDAZINE- 3,5-DIONA AND RELATED COMPOUNDS AS INHIBITORS OF ORTHOMYXOVIRUS REPLICATION FOR THE TREATMENT OF INFLUENZA. |
| abstract |
The current disclosure refers to 10-(di(phenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1, 2-b]pyridazine-3,5-dione and related compounds of Formula (A) as inhibitors of orthomyxovirus replication for the treatment of influenza. (see formula) A specific preferred compound is, for example, (9aR,10S)-10-((S)-(4-fluorophenyl)(3-(trifluoromethyl)phenyl)methyl)-4-hydroxy-8,9, 9a,10-tetrahydro-7H-pyrrolo[1',2':4,5]pyrazino[1,2b]pyridazine-3,5-dione (example 1). |