| abstract |
Provided herein are transdermal delivery devices comprising dextromethorphan. The transdermal delivery device may be characterized by the novel design, for example, with an adhesive layer and a reservoir layer, with an adhesive layer comprising a mixture of two adhesives, and with a skin penetration enhancer, for example. , in an amount that can significantly enhance the flux of dextromethorphan. The transdermal delivery device may also be characterized by its in vitro and/or in vivo release profile, for example, which may provide a desired pharmacokinetic profile described herein. Also provided herein are methods of administering dextromethorphan and methods of treating a disease or disorder described herein with the transdermal delivery device herein. |