| abstract |
The present invention provides methods for ketone synthesis involving a Ni/Zr mediated coupling reaction; Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (eg, halichondrin A, B, C; homohalicondrin A, B, C; norhalicondrin A, B, C) and analogs thereof; Therefore, the present invention also provides useful synthetic methods for the synthesis of halichondrins and their analogs; Also provided herein are compounds (ie, intermediates) useful in the synthesis of halichondrins and analogs thereof; In particular, the present invention provides methods and compounds useful in the synthesis of the compound of formula (H3-A): (see formula). |