http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2019000406-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_16a2ba9ae645bf469800ae7a06afbcbd |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate | 2019-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_086aacefbde9c2a389caf0b1351b8706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96a1f2b0a2b6384dc93a847b725e78d6 |
| publicationDate | 2020-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2019000406-A |
| titleOfInvention | INACTIVATION OF THE EEF3 PROTEIN AS A METHOD TO COMBAT THE SPECIES OF FUNGI CANDIDA SPP. |
| abstract | The mortality rate from invasive infections with opportunistic fungi (candidemia) in hospitals is especially high in immunosuppressed patients. These infections are caused by species of the genus Candida, an issue that is currently unresolved. To combat this enormous problem, we propose to target a fundamental process for life to exist: protein synthesis, also called "translation", since a few years ago a protein was discovered that is absolutely essential for translation in fungi, called eEF3 (for eukaryotic elongation factor 3). Regarding this factor, two key observations have been made: 1) that the deletion of the eEF3 gene encoding eEF3 in Saccharomyces cerevisiae (called the YEF3 gene in this yeast) is lethal for these organisms; and 2) that eEF3 is a factor that only exists in fungi, that is, its gene is not present in any animal, plant or bacteria. These two aspects make eEF3 a molecule that can be targeted by drugs that inactivate it to specifically combat species of pathogenic fungi, and that at the same time do not affect the translation apparatus of other living beings. For this application, we have experimentally shown that deletion of the eEF3 gene (sometimes referred to as EF3 in some databases) causes lethality in the species Candida glabrata. Therefore, in this application we intend to patent as innovative 1) the inactivation of eEF3 as a method of combating Candida species, that is, the alternative of searching for drugs that act specifically against Candida eEF3 with lethal results for such organisms. And apply for the patent of the artificial strain ?ura3::KANMX, ?eEF3::NATMX <pYC12-eEF3> of C. glabrata, which we have generated to demonstrate that the elimination of the eEF3 gene causes lethality in C. gabrata; 2) we also intend to patent the method to generate it; and 3) as well as the definition that eEF3 is capable of being specifically inactivated with drugs or antibodies directed at the ABC1 and ABC2 domains and Chromium. |
| priorityDate | 2019-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.