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filingDate 2017-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38d858ce7bd53b95e02737e23ae65d0d
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publicationDate 2019-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MX-2018014867-A
titleOfInvention METHOD OF MASS SPECTROMETRY FOR DETECTION AND QUANTIFICATION OF METABOLITES.
abstract A method for determining the amount of one or more analytes in a sample by mass spectrometry is described. The one or more analytes are selected from the group consisting of alpha-hydroxybutyrate (2-HB), linoleoyl LPC (LGPC), oleic acid, 3-hydroxybutyrate (3-HB), 4-methyl-2-oxopentanoate (4-MOP ), pantothenate, and serine. The method includes: a) subjecting the sample to an ionization source under appropriate conditions to produce one or more ions detectable by mass spectrometry of each of the one or more of the analytes, where the analytes are not derivatized before ionization ; b) measure, by tandem mass spectrometry, the amount of the one or more ions of each of the one or more analytes; c) use the measured amount of the one or more ions to determine the amount of each of the one or more analytes in the sample.
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