abstract |
The present application refers to the crystalline forms A, D, F, G and I of the obetolic acid. (see Formula) These crystalline forms are useful in the production of obetolic acid (in particular its purification), which is a useful drug for the treatment or prevention of a disease or condition mediated by FXR, cardiovascular diseases or cholestatic liver disease, and to reduce HDL cholesterol, to reduce triglycerides in a mammal or to inhibit fibrosis. |