| abstract |
The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a class of alkynyl pyridine prolyl hydroxylase (I) inhibitors. The experiment shows that said compound has a good prolyl hydroxylase inhibition activity and can enhance the generation and secretion of erythropoietin in cellular or animal models, and therefore can promote the generation of red blood cells, and can be used for the treatment or Anemia prevention, such as chronic kidney disease anemia and ischemic diseases, such as ischemic strokes, myocardial ischemia and other related diseases. The present invention also describes a method for preparing said compound. |