| abstract |
Compounds of Formula I are disclosed, including pharmaceutically acceptable salts, pharmaceutical compositions comprising the compounds, methods of preparing the compounds and their use in inhibiting HIV integrase and treating HIV or AIDS infected. In the compounds of the formula (I); R1 is selected from hydrogen, alkyl or cycloalkyl; R2 is selected from tetrahydroisoquinolinyl and is substituted with 1 R6 substituent and also with 0-3 halo or alkyl substituents; R3 is selected from azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, homopiperidinyl, homopiperazinyl or homomorpholinyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy and haloalkoxy; R4 is selected from alkyl or haloalkyl; R5 is alkyl; R6 is selected from Ar1, (Ar1) alkyl, (chromanyl) alkyl, cyanocycloalkyl or (dihydrobenzodioxynil) alkyl; and Ar1 is phenyl substituted with 0-5 substituents selected from cyano, halo, alkyl, cycloalkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, (hydroxy) alkoxy, (alkoxy) alkoxy, phenoxy, benzyloxy, carboxy, phenyl and cyanocycloalkyl. (see Formula). |