| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a2b2c13638e198ec3ca3d49d181123 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C277-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-18 |
| filingDate |
2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f8b054f8e268f411975725201203e14 |
| publicationDate |
2018-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-2018001548-A |
| titleOfInvention |
PROCEDURE FOR THE PREPARATION OF COMPOUND N- (3,5-DIMETHYLPHENYL) -N '- (2-TRIFLUOROMETILFENIL) GUANIDINE. |
| abstract |
The present invention relates to a process for the preparation of the compound N- (3,5-dimethylphenyl) -N '- (2-trifluorometi lphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula ( II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; to a crystalline solid form of the compound of formula (I), in particular the crystalline solid form A; to a pharmaceutical composition comprising them; and for use as a medicament, in particular for the treatment of a condition mediated by Rho-GTPase cellular proteins. |
| priorityDate |
2015-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |