| abstract |
The invention relates to phosphoinositide 3-kinase (PI3K), mammalian objective compounds of rapamycin (mTOR) and PI3K-related kinase inhibitor (PIKK) of the formula (I), (see Formula). wherein X1, X2 and X3 are N or CH, with the proviso that at least two of X1, X2 and X3 are N; And it is N or CH. These compounds are useful, either individually or in combination with other therapeutic agents for the treatment of disorders mediated by lipid kinases. |