| abstract |
The present description provides conjugate compositions of drugs, and compositions and methods for preparing and using them. In some embodiments, the present invention relates to directed conjugated compositions comprising cysteine-containing domains (CCD) linked to the target portions, extended recombinant polypeptides (XTEN) and cleavable portions of peptide, with pharmacologically active payload drugs crosslinked to the cysteine residues, resulting in compositions that can be cleaved by proteases associated with target tissues. The invention also provides methods for producing the directed conjugate compositions to use the directed conjugate compositions. |