| abstract |
The present invention provides compounds of the formula (II) (for example, compounds of formula (I)), and pharmaceutical compositions thereof; it is believed that the compounds of the formula (II) are bromodomain binders and / or bromodomain containing proteins (eg, bromine and extra terminal proteins (BET)); Methods, uses and kits are also provided that use the compounds and pharmaceutical compositions to inhibit the activity (eg, increased activity) of bromodomins and / or proteins containing bromodomain and to treat and / or prevent in a subject the diseases associated with bromodomains or proteins containing bromodomain (for example, proliferative diseases, cardiovascular diseases, viral infections, fibrous diseases, metabolic diseases, endocrine diseases and radiotoxemia); Compounds, pharmaceutical compositions and kits are also useful for contraception for men. (see Formula). |