http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2016009505-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e077c50cbe526f3936e752e978a1cdf0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C315-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-20 |
| filingDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55ce6024f04dfdb11d2586913d8f76ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cee71ad168e36b8ede00580365fd7e11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb31cd9ad552a7b2022c7412d756f610 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e63bdd690b9063fe9626aafc1b80e66 |
| publicationDate | 2016-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2016009505-A |
| titleOfInvention | METHOD FOR SYNTHESIZING FLORPHENICOL. |
| abstract | The present invention discloses a new method of synthesis of florfenicol. The method synthesizes florfenicol products that meet the requirements of the Drug Administration through a series of combinations of cyclization, selective reduction, fluorinated open ring, deprotection and acylation, conversion reaction of the esterified sulfo hydroxy acid configuration, hydrolysis reaction and the like The synthesis method of the present invention utilizing a three-member ring of chiral amine closed ring aziridine that uses a physical separation method to repeatedly purify the high yield chiral amino ketone to obtain the unique R configuration, and utilizes the reduction selective and converts the configuration to obtain florfenicol, which improves the economy of the atom, while avoiding the contamination of wastewater caused by the existing process, and greatly reduces costs for wastewater treatment and reduces pollution to The environment, therefore reduces costs and simplifies the process. In addition, the present invention utilizes hydrofluoride triethylamine as a fluorinated open ring reagent, to improve the safety of a reaction liquid compared to a gas reaction and reduce equipment corrosion, which facilitates industrial production. |
| priorityDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.