| abstract |
The present invention relates to a polypeptide comprising a first polypeptide and a second polypeptide, each comprising in the N-terminal to C-terminal direction, at least a portion of the immunoglobulin hinge region, comprising one or more cysteine residues, an immunoglobulin CH2 domain and an immunoglobulin CH3 domain, wherein the first, second or first and second polypeptides comprise the Y436A mutation (numbering according to the EU index). |