http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2015017343-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45590828fce09c7cdec31e2339d1a132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68fc517e8b5cda03df98ac258ed9bd38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d5da5d8ea88666396ad4b4657365105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f151c52cae61076b2c9af29a44b0b35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf5c0d1b2fe1c33e19732b62e5d955fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_419f28913db0c4b653ec69a5c26e84df |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2015017343-A |
| titleOfInvention | DERIVATIVES OF PIRROLOPIRIDINA OR PIRAZOLOPIRIDINA. |
| abstract | The present invention relates to compounds of the formula I in which R 1 is a halogen, a lower alkyl, a lower alkoxy, cyano, phenyl, C (O) NHCH 3, C (O) NH 2, a lower alkyl substituted with a halogen or is a five-membered heteroaryl group, optionally substituted with a lower alkyl; Y1 is N or CH; Y2 is CH; and if Y1 is CH, Y1 and Y2 can form a ring together with the C atoms to which they are attached, and include -CH = N-N (CH3) -, -CH = N-N (H) -; X is CH or N; R is (CH2) m-cycloalkyl, optionally substituted with a hydroxy, a lower alkoxy or a lower alkyl, or is tetrahydropyran, optionally substituted with a hydroxy, or is a lower alkoxy, substituted with a hydroxy, or is a lower alkyl substituted with a one or two hydroxy, or is (CH2) m-pyridinyl, optionally substituted with a hydroxy, a lower alkyl or a lower alkyl substituted with a hydroxy, or is L-phenyl, optionally substituted with a hydroxy, a lower alkyl or an alkyl bottom substituted with a hydroxy, and L is a bond, - CH (CH2OH) - or -CH2CH (OH) -; n is 0, 1 or 2; m is 0 or 1; or to the pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and / or the optical isomers thereof. The compounds of the present invention are positive allosteric modulators of the M1 muscarinic receptor (PAM) and are therefore useful in the treatment of diseases mediated by the M1 muscarinic receptor, such as Alzheimer's disease, cognitive dysfunction, schizophrenia, pain or sleep disorders. |
| priorityDate | 2013-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.