| abstract |
The present invention relates to compounds of Formula (I) (see Formula) and salts thereof, wherein: Q is: (see Formulas) R1 is -C (CH3) 2OH, -NHC (= O) C (CH3 ) 3, -N (CH3) 2, or -CH2Rd; R2 is Cl or -CH3 R3 is H, F, or -CH3; Ra is H or -CH3; Rb is H, F, Cl, or -OCH3; Rc; H or F; and Rd is -OH, -OCH3, -NHC (= O) CH3, or (see Formula) Methods for using such compounds as Bruton tyrosine kinase inhibitors (Btk), and pharmaceutical compositions comprising such compounds are also described. These compounds are useful in the treatment, prevention or decrease of the progress of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease. |