http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2015015432-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cdd6c9aa2a56078633fd99c1537ae |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-98 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 |
| filingDate | 2014-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3c2ef92912e29936eb92b9f8631bd2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe64666db44e191aef120b9eab3ed435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cc4284f3da70ca58fca59cb26a2d0f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7be29d891031525ed7ba112df7512027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8639f0314baf43a54693166a72d99ec6 |
| publicationDate | 2016-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2015015432-A |
| titleOfInvention | AN IMPROVED PROCESS FOR THE PREPARATION OF (3R, 4R) - (1-BENCILO-4-ME TILPIPERIDINA-3-IL) -METILAMINE. |
| abstract | The present invention relates to an improved and efficient process for the preparation of (3R, 4R) - (1-benzyl-4-methyl-piper idine-3-yl) -methylamine comprising: (a) N-acylation of 3 -amino-4-methyl pyridine; (b) quaternization of 3-acetylamino-4-methyl peridine using benzyl halide; (c) partial reduction of quaternized 3-acetylamino-4-methyl peridine by means of sodium borohydride in methanol or water; (d) hydrolysis of the product partially reduced to 1-benzyl-4-methylpiperidine-3-one in the presence of acid; (e) 1-benzyl-4-methylpiperidine-3-one reducing animation using methanolic methylamine in the presence of titanium (IV) isopropoxide in methanol; (f) Resolution of 1-benzyl-4-methylpiperidine-3-yl) -methyl amine using ditholuoyl (L) tartaric acid to obtain (3R, 4R-1-benzyl-4-methylpiperidine-3-yl) -methylamine. The invention also relates to novel intermediates. (see Formulas) where R, R 'and X are as described in the description. |
| priorityDate | 2013-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.