| abstract |
Methods for preparing macrolides are provided herein by coupling a half of East and West, followed by macrocyclization, to provide macrolides, including both known and novel macrolides; intermediates in the synthesis of macrolides that include halves of East and West are also provided; Pharmaceutical compositions and methods for treating infectious diseases and inflammatory conditions, which use the inventive macrolides, are also provided; In addition, a general methodology of diastereoselective aldol used in the synthesis of the Midwest is provided. |