abstract |
The present invention provides an improved method for large-scale production of the acid compound 4- {[(2R, 3S, 4R, 5S) -3 - (3-chloro-2-fluoro-phenyl) -4- (4-chloro -2-fluoro-phenyl) -4-cyano-5- (2,2-dimethyl-propyl) -pyrrolidin-2-carbonyl] -amino} -3-methoxy-benzoic or. |