| abstract |
The present invention relates to new substituted pyrazolo [3,4-d] pyrimidine compounds of the general formula (I) that have a high affinity for sigma receptors, especially the sigma-1 receptor, as well as the process for their preparation, compositions that comprise them and their use as medicines for the treatment of eg pain. n is selected from 1, 2, 3 04; R1 represents an optionally substituted aryl or heteroaryl carbon-bonded radical; R2 and R3 independently represent a hydrogen atom, an optionally substituted aliphatic, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl radical, or R2 and R3 together with the nitrogen bridge form an optionally substituted heterocycloalkyl radical or radical heteroaryl. |