| abstract |
A Fc region fusion polypeptide or Fc region conjugate comprising one to four incretin receptor ligand polypeptides and a variant human Fc region with a mutation of the amino acid residue at position 329 and at least one is reported herein. additional mutation of at least one amino acid selected from the group comprising amino acid residues at positions 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 to a different residue, wherein the residues in The Fc region is numbered according to the Kabat EU index and its use as a medicine. |