| abstract |
A medicament for the treatment of diseases associated with cholinergic properties in the central nervous system (CNS) and / or peripheral nervous system (SNP), diseases associated with smooth muscle contraction, endocrine disorders, neurodegenerative disorders and the like, comprising a compound of formula (I): (see Formula) where A is CR1E or a nitrogen atom, XYZ is N-CO-NR3AR3B, the similar, R1A to R1E are each independently a hydrogen atom and the similar, R2A to R2D they are each independently a hydrogen atom and the like, R3A and R3B are each independently an optionally substituted C3-10 cycloalkyl and the similar and n is 1 or 2 or a pharmaceutically acceptable salt thereof, which exhibits potent modulating effects on the nicotinic acetylcholine a7 receptor activity (a7 nAChR). |