| abstract |
The present invention relates to new carboxamide compounds and their use for the manufacture of a medicament. Carboxamide compounds are inhibitors of calpains (calcium-dependent cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds to treat a disorder associated with high calpain activity. The carboxamide compounds are compounds of the general formula (I) wherein R1, R2 and n have the meanings mentioned in the claims and the description, Y is a radical of the formulas (Y1) or (Y2) where # indicates the point of attachment from Y to the pyridine ring, R3, R4, R5, Ry m have the meanings mentioned in the claims and the description, A is is (CH2) p where p is 1, 2, 3 or 4, where one or two hydrogen atoms they can be replaced by a radical R6, where A is attached to the 3 or 4 position of the pyrazole radical and R6 has the meaning mentioned in the claims and the description; A1 is (CH2) q where q is 0, 1, 2 or 3, where one or two hydrogen atoms can be replaced by halogen or C1-C4-alkyl; and A2 is (CH2) r where r is 0, 1, 2 or 3, where one or two hydrogen atoms can be replaced by halogen or C1-C4-alkyl, with the proviso that r + q is 2, 3, 4 , 5 or 6; their tautomers, the hydrates thereof, the pharmaceutically acceptable salts of the carboxamide compounds (I), the prodrugs of (I) and the pharmaceutically acceptable salts of the prodrugs, tautomers or hydrates of (I). (see Formulas). |