| abstract |
This refers to a nucleic acid molecule with the ability to bind CGRP, wherein the nucleic acid molecule comprises a central nucleotide extension, wherein the central nucleotide extension comprises a nucleotide sequence of 5 'HWn1n2YGGAn3An4UMn5n6Yn7n8n9n10n11 Kn12 Rn13ADn14 n14n15AGn16Un17Cn18n19Un20n21 3 '[SEQ ID NO: 99], where H, W, Y, G, A, U, M, B, K, R, D, C are ribonucleotides, and n1 is R or dG, n2 is U or dT, n3 is K or dG, n4 is C or dC, n5 is M or dC, n6 is B or dU, n7 is N or dG, n8 is Y or dT, n9 is N or dC, n10 is R or dG, n11 is V or dA, n12 is K or dT or dU, n13 is G or dG, n14 is A or dA, n15 is U or dT, n16 is R or dG, n17 is Y or dC, n18 is C or dC, n19 is B or dC, n20 is C or dC, n21 is C or dC, and dG, dT, dC, dA and dU are 2'-deoxyribonucleotides. |