| abstract |
The present invention relates to the chitosan polymer derivatives of the formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind or associate with dimers of the integrin alpha-4-beta-1 (a4ß1) and alpha-V-beta-3 (aVß3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins. |