| abstract |
The invention relates to a process for the preparation of travoprost of formula (I), which comprises that, the compound of formula (II), is stereoselectively reduced, the resulting compound of formula (III), crystallizes if desired, reduces the lactone group of the compound of formula (III), the p-phenyl-benzoyl protecting group of the compound of formula (IV) thus obtained is eliminated, the resulting triol of formula (V), is, if desired after crystallization, transformed by the Wittig reaction in the acid of formula (VI), which is then esterified. |