| abstract |
The inventors of the present invention discovered that the loss, of blood plasma, of antigens containing two or more antigen binding units, is accelerated by forming a large immunocomplex containing two or more molecules of an antigen binding molecule ( for example, an antibody), and an antigen having two or more antigen binding units (epitopes). Furthermore, the inventors discovered that the present invention can be achieved by further accelerating the loss of the antigens by using the aforementioned feature and by using an antigen binding molecule that exerts the ion dependent antigen binding activity. |