| abstract |
Compounds, compositions, and methods of treatment and prevention of HIV infection are described; the compounds are JAK inhibitors of pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidine; Also described are combinations of these JAK inhibitors and additional antiretroviral compounds, such as NRTI, NNRTI, integrase inhibitors, entry inhibitors, protease inhibitors, and the like; In one embodiment, the combinations include a combination of adenine, cytosine, thymidine, and guanine nucleoside antiviral agents, optionally in additional combination with at least one additional antiviral agent that works through a different mechanism than an analogue. nucleoside; This combination has the potential to eliminate the presence of HIV in an infected patient. |