| abstract |
The present invention relates to antibodies and antigen binding fragment thereof that bind to the extracellular domain of the HER3 receptor and inhibit various functions related to HER3 receptors by ligand-dependent and / or ligand-independent mechanisms. Compositions with increased half-life are also provided. In addition, the invention provides compositions and methods for the diagnosis and treatment of diseases associated with HER3-mediated signal transduction. |