| abstract |
The compounds are provided, the use of said compounds in the treatment, for example the treatment of microbial infections, particularly by Gram-negative bacteria. The compounds are based on polymyxin and are represented by formula (I): and pharmaceutically acceptable salts thereof, where X is - NHC (O) -, -C (O) -, -OC (O) -, - CH2- or SO2-; R5 represents alkyl of 10 to 12 carbon atoms (heterocyclyl of 4 to 6 carbon atoms), or alkyl of 2 to 12 carbon atoms or alkyl of O to 12 carbon atoms (cycloalkyl of 3 to 8), and alkyl or the cycloalkyl carries one, two or three hydroxyl groups, or a group -NF6R7, or a group -NR6R7 and one or two hydroxyl groups; and R1 to R4 and R6 to R8 are as defined in the description. |