| abstract |
Aminopyrimidine compounds, pharmaceutical compositions containing those compounds and uses of the compounds and compositions as modulators of CK1, CK1? 1, CK1? 2, or CK1? 3, Pim 1, Pim2, Pim3, the TGFβ pathway, the route of Wnt, the JAK / STAT pathway, the AKT pathway and / or the mTOR pathway. Uses are also described for the treatment or prevention of a wide range of therapeutic indications due at least in part to the aberrant physiological activity of CK1, CK1? 1, CK1? 2, or CK1? 3, CK2, Pim 1, Pim2, Pim3 , the TGFβ pathway, the Wnt pathway, the JAK / STAT pathway, the AKT pathway and / or the mTOR pathway. |