| abstract |
The present invention is an aqueous stabilized etanercept formulation to reduce instability, aggregation and / or fragmentation of etanercept, said formulation comprises from about 25 to about 75 mg / ml of etanercept and one or more stabilizers, wherein the stabilizers are select from the group consisting of sodium chloride; and sodium chloride in combination with sucrose or trehalose; and a combination of sodium chloride, sucrose and trehalose; Several technical terms used in the following analysis are defined below in the section entitled "definitions" and through the rest of the specification the stabilized etanercept formulations of the present invention produce long-term storage stability. |