titleOfInvention |
N-ACIL-5,6,7, (8-REPLACED) -TETRAHYDRO- [1,2,4] TRIAZOLO [4,3-A] PIRA QUIRAL ZINAS, NOVEDOSAS, AS SELECTIVE ANTAGONISTS OF NK-3 RECEPTOR; PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN DISORDERS MEDIATED BY NK-3 RECEPTOR AND ITS CHIRAL SYNTHESIS. |
abstract |
The present invention relates to novel compounds of the formula I: (see Formula) and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7, (8-substituted) -tetrahydro- [1,2,4] triazolo [4,3-a] pyrazines using N-sp3 protecting groups. The invention also provides intermediaries for use in the synthesis of compounds of the formula I. |