| abstract |
The present inventions refer to phenyl-3-aza-bicyclo [3, 1] 0 substituted hex3-yl-methanones of the general formula (I) (see Formula) wherein R1, R2, R3, R4, R5 and R6 they are as described herein or their salts, preferably, their pharmaceutically acceptable salts. The invention also relates to the preparation of said compounds, pharmaceutical compositions comprising a compound according to the general formula (I) and the use of said compounds for the treatment of various conditions such as conditions related to positive and negative symptoms of schizophrenia. , as well as cognitive disorders associated with schizophrenia, Alzheimer's disease and other neurological and psychiatric disorders. The compounds of the invention show inhibitory properties of the glycine 1 transporter (GIyT1). |