| abstract |
The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and kits capable of obtaining a protective immune response against JC polyomavirus (JCV) are described, which can be used, for example, for therapy or for prevention of progressive multifocal leukoencephalopathy (PML) and / or inflammatory reconstitution immune syndrome to multifocal leukoencephalopathy. progressive (PML-IRIS). Endangered individuals of such PML or PML-IRIS may, for example, be immunocompromised or immunosuppressed patients or patients who have an autoimmune disease eligible for immunosuppressive treatment. The invention also relates to compositions that include at least one CD4 + epitope of a JCV protein and to therapeutic, prophylactic and diagnostic uses thereof. |