| abstract |
The compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of disorders and conditions mediated by TRPM8 and can be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. The compounds of Formula I have the following structure: (see Formula) where definitions of the variables are provided herein. |