| abstract |
In its many embodiments, the present invention provides certain iminothiazine dioxide compounds, including compound of Formula (I): (See Formula) and tautomers and stereoisomers thereof and pharmaceutically acceptable salts of said compounds, said tautomers and said stereoisomers, in which each of the variables shown in the formula is as defined in this document; the novel compounds of the invention may be useful as BACE inhibitors and / or for the treatment and prevention of various pathologies related thereto; Also described are pharmaceutical compositions comprising one or more of said compounds (alone and together with one or more different active agents), and methods for their preparation and use, including Alzheimer's disease. |