abstract |
The invention discloses a method for the preparation of 6-chloro-3,5-dioxohexanoate tert-butyl from Meldrum acid derivative and its use for the preparation of (4R, 6S) - (6-hydroxymethyl-2,2 -dimethyl-1,3-dioxan-4-yl) tert-butyl acetate (BHA), Rosuvastatin and Atorvastatin. |