| abstract |
The invention relates to new compounds of the formula I: (See Formula) in which A, Y, R1, R2 and the subscript b have in each case the meaning defined herein and the compounds of the formula I and their stereoisomers, isomers geometric, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts or prodrugs. The compounds of the formula I and the pharmaceutical compositions containing them are useful for the treatment of diseases and disorders, in which an unwanted or over-activated signaling of NF-KB is observed. |