| abstract |
Strains of metabolically designed microorganisms, such as bacterial strains, are revealed in which there is an increased use of malonyl-CoA for the production of a chemical. Such chemicals include polyketides, 3-hydroxypropionic acid and several other chemicals described herein. Production methods can also be applied to several additional downstream products, such as consumer products. In several embodiments, modifications to a microorganism and / or culture system divert, at least temporarily, the use of malonyl-CoA from the fatty acid biosynthesis pathway and thereby provide the use of malonyl-CoA for a chemical. Different from a fatty acid. In several embodiments, the fatty acid biosynthesis pathway is modulated to produce specific fatty acids or combinations of fatty acids. |