| abstract |
The present invention relates to pyridazine derivatives, to compositions comprising therapeutically effective amounts of those pyridazine derivatives and the methods of use of those derivatives or compositions in the treatment of disorders of the central nervous system (CNS) with cognitive impairment. , which respond to GABAA receptor agonists containing the subunit for example, age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's disease (AD), prodromal AD, post traumatic stress disorder ( PTSD), schizophrenia and cognitive impairment related to cancer therapy. |